The systemic vulnerability of female athletes to ACL injuries has long demanded a coordinated, data-driven response beyond isolated club efforts. FIFPRO’s expansion of its Project ACL study into the National Women’s Soccer League, in partnership with the NWSL and its Players Association, represents a significant escalation in that pursuit. Building on its 2024 launch with England’s Women’s Super League, the global players’ union is now incorporating a major North American cohort. This cross-league collaboration, noted in a CBS Sports report, aims to generate comparative data on training loads, travel, and playing surfaces that is critical for evidence-based prevention. The initiative acknowledges the injury’s disproportionate impact as a barrier to professional stability and competitive integrity. Whether this research translates into enforceable standards across federations and leagues remains the unresolved challenge.