Markets Desk

Markets Desk · 9 AM Update

Good afternoon and welcome to Markets Desk.

In the space economy, Vast, the startup racing to build a commercial replacement for the International Space Station, has trimmed roughly four percent of its workforce this week. The company is framing the cuts as performance-related rather than financial, and says it intends to backfill the positions — a signal that headcount strategy, not runway, is driving the decision.

Shifting to biotech, Akeso has cleared a significant regulatory hurdle in China, with its next-generation antibody-drug conjugate AK157D1 receiving clinical trial clearance from the National Medical Products Administration for use in solid tumors. The drug targets a protein called B7-H3, a pathway that has drawn considerable oncology investment, and this Phase One green light moves Akeso meaningfully closer to human data.

And on the ground in Gary, Indiana, a story that puts a human face on infrastructure fragility — a derecho storm that hit on August eleventh knocked out power to tens of thousands of utility customers, and as of Thursday more than fifty-seven thousand remain in the dark. One restaurant owner reports losing nineteen thousand dollars in sales over eight days, a ninety percent revenue collapse that underscores how devastating prolonged outages are for small operators with no buffer.

That's the tape. Markets Desk, signing off the floor.

Sources

  1. https://www.businessinsider.com/space-station-startup-vast-cuts-jobs-layoffs-2026-8
  2. https://www.businessinsider.com/restaurant-owner-lost-power-week-19000-sales-gary-indiana-blackout-2026-8
  3. https://www.forbes.com/sites/tomsanderson/2026/08/21/real-madrid-coach-mourinho-wants-players-to-die-for-him-in-first-press-conference/
  4. https://www.nasdaq.com/articles/akesos-ak157d1-cleared-phase-i-trial-solid-tumors
  5. https://www.forbes.com/sites/davidhambling/2026/08/21/will-russias-gamble-on-jet-powered-drones-pay-off/
  6. https://www.nasdaq.com/articles/these-3-artificial-intelligence-stocks-can-double-end-2027
  7. https://www.nasdaq.com/articles/adaptin-begins-patient-enrollment-phase-1-trial-aptn-101-glioblastoma
  8. https://www.forbes.com/sites/joshshepardson/2026/08/21/fridays-best-mlb-home-run-props-have-long-odds-basallo-and-lowe/
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